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NexACT® Biography of Related Publications

  1. Pfister, W., and Frank, D. (2007) The novel permeation enhancers dodecyl-2-N,N-dimethylaminopropionate (DDAIP) and HCl salt: physicochemical properties, preclinical safety and in vitro permeation enhancement. Submitted for Poster presentation at the 34th Annual Meeting and Exposition of the Controlled Release Society (July 7-11, 2007). Poster

  2. Pfister, W., Li, M., and Frank, D. (2006) Development of the novel permeation enhancers dodecyl-2-N,N-dimethylaminopropionate (DDAIP) and HCl salt: physicochemical properties, preclinical safety and in vitro permeation enhancement. Poster Number M1183, 2006 AAPS Annual Meeting and Exposition, October 29-November 2, 2006 San Antonio, TX. Poster

  3. Ghannoum, M., Dutta, S., Pfister, W., Lu, M., and Isham, N. (2006) Determination of antifungal activity of terbinafine HCl nail lacquer by time-kill assay, Poster, P1917, Infection (Fungal), American Academy of Dermatology 64th Annual Meeting, San Francisco, CA, March 3-7 (2006). Poster

  4. Lehman, P.A., Franz, T.J., and Pfister, W. (2006) In vitro permeation of terbinafine through human nails from terbinafine HCl nail lacquer formulations, PPP 2006 Tenth International Conference: Perspectives in Percutaneous Penetration, La Grande Motte, France April 18-22, 2006, Poster

  5. Long, L. Isham, N., Catalano, V., Love, W.E., VanDerStraten, M, Pfister, W., Lu, M. and Ghannoum, M. (2006) In vitro evaluation of terbinafine HCl nail lacquer in a bovine hoof penetration bioassay, Poster, P1904, Infection (Fungal), American Academy of Dermatology 64th Annual Meeting, San Francisco, CA, March 3-7 (2006). Poster

  6. Lehman, P.A., Franz, T.J., Lu M.Q., and Pfister, W. (2005) In vitro permeation of terbinafine through human nails from terbinafine HCl nail lacquer formulations, 2006 AAPS Annual Meeting and Exposition, November 6-10, 2005, Nashville, TN, Poster # R6072. Poster

  7. Ghannoum, M., Isham, N., Pfister, W.R. and Lu, M. (2005) In vitro testing of experimental nail lacquer for the treatment of fungal infections, Poster, P1822, Infection (Fungal), American Academy of Dermatology 63rd Annual Meeting, New Orleans, LA, February 19 (2005). Supplement, J. Am. Acad. Derm. 52(3): P127 (P1822), March (2005). Paper

  8. Hossain, M., Ghannoum, M., Pfister, W.R., and Lu, M., (2005) Efficacy of terbinafine HCl nail lacquer formulations in a guinea pig model of T. mentagrophytes-dermatophytosis, Poster, P29, Poster Discussion Session PDS 494: Infections and Anti-Infectives, American Academy of Dermatology 63rd Annual Meeting, New Orleans, LA, February 20 (2005). Supplement, J. Am. Acad. Derm. 52(3): P8 (P29), March (2005). Poster

  9. Vavrova, K., Zbytovska, J., and Hrabalek, A. (2005) Amphiphilic transdermal permeation enhancers: structure-activity relationships. Curr Med. Chem. 12(19): 2273-2291. Poster

  10. Wolka, A.M., Rytting, J.H., Reed, B.L., Finn, B.C. (2004) The interaction of the penetration enhancer DDAIP with a phospholipid model membrane. Int. J. Pharm. 271: 5-10. Poster

  11. Yeager, J., Büyüktimkin, N., and Büyüktimkin, S. (November 26, 2002) Compositions and methods for amelioration of human female sexual dysfunction. U.S. Patent 6,486,207 B2. Patent

  12. Büyüktimkin, S., Büyüktimkin, N., and Yeager, J. (July 2, 2002) Topical compositions containing prostaglandin E1. U.S. Patent 6,414,028 B1. Patent

  13. Yeager, J., Büyüktimkin, A., and Büyüktimkin, S. (November 27, 2001) Prostaglandin compositions and methods of treatment for male erectile dysfunction. U.S. Patent 6,323,241 B1. Patent

  14. Fujii, M., Buyuktimkin, S., Buyuktimkin, N, and Rytting, J.H. (2002) Enhancement of skin permeation of miconazole by phospholipid and dodecyl-2-(N,N-dimethyl amino)propionate (DDAIP). Int. J. Pharm. 2; 234(1-2): 121-128. Paper

  15. Hadgraft, J. (2001) Perspectives on dermal and transdermal delivery. drug delivery Systems and Science. 1(4): 107-112. Paper

  16. Hadgraft, J. (2001) Modulation of the barrier function of the Skin. Skin Pharmacol. Appl. Physiol. 14(Suppl): 72-81. Paper

  17. Büyüktimkin, S., and Büyüktimkin, N. (September 12, 2000) Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate. U.S. Patent 6,118,020. Patent

  18. Büyüktimkin, S., Büyüktimkin, N. and Yeager, J. L. (July 4, 2000) Topical compositions for non-steroidal topical drug delivery . U.S. Patent 6,083,996. Patent

  19. Büyüktimkin, S., Büyüktimkin, N. and Yeager, J. L. (April 4, 2000) Topical compositions for prostaglandin E1 delivery. U.S. Patent 6,046,244. Patent

  20. Büyüktimkin, S., Büyüktimkin, N., and Yeager, J. L. (2000) Permeation of alprostadil through animal membranes. Abstract 1147, AAPS Annual Meeting, Oct. 29-Nov. 2, 2000, Indianapolis. Abstract

  21. DeMarco, K., Büyüktimkin, S., Büyüktimkin, N., and Rytting J. H. (2000) Transdermal delivery of prazosin through shed snake skin in the presence of azone and limonene. Abstract 1146, AAPS Annual Meeting, Oct. 29-Nov. 2, 2000, Indianapolis. Patent

  22. Büyüktimkin, S., Büyüktimkin, N., and Yeager, J. L. (1999) Topical delivery of alprostadil through various membranes. Abstract 1039, AAPS Annual Meeting, Nov. 14-18, 1999, New Orleans. Patent

  23. Büyüktimkin, T., Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H (1998) Ternary phase diagrams of biodegradable penetration enhancers, DDAIP, DAIPD, DAIPM and some other esters with ethanol, isopropanol, propylene glycol and water. AAPS Annual Meeting, San Francisco, Pharm. Sci. Suppl. Vol 1 PDD 3602: S-532. Paper

  24. Büyüktimkin, S., Büyüktimkin, N., Ersoy, N., Tanol, M., Walters, J. L., Cohen, A. R., and Rytting, J. H. (1998) Influence of storage conditions of shed snake skin of three species on their lipid composition, transdermal delivery and retention of diphenhydramine, hydrocortisone, and ketoprofen. AAPS Annual Meeting, San Francisco, Pharm. Sci. Suppl. Vol 1 PDD 3603: S-532. Abstract

  25. Büyüktimkin, T., Büyüktimkin, S., Büyüktimkin, N., Babb, L. D., and Rytting, J. H (1998) Penetration, skin retention and solubility profile of the biodegradable penetration enhancer Dodecyl-2-(N,N-dimethylamino)-propionate (DDAIP) through shed snake skin. AAPS Annual Meeting, San Francisco, Pharm. Sci. Suppl. Vol 1 PDD 3604: S-533. Abstract

  26. Diab, H., Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H (1998) Effect of ethanol and the penetration enhancer Dodecyl-2-(N,N-dimethylamino)-propionate (DDAIP) on the skin permeation of flurbiprofen through shed snake skin. AAPS Annual Meeting, San Francisco, Pharm. Sci. Suppl. Vol 1 PDD 3605: S-533. Abstract

  27. Wolka, A. M., Büyüktimkin, N., Büyüktimkin, S., and Rytting, J. H (1998) pH dependence of solubility, transdermal penetration, and retention of acyclovir using a shed snakeskin model. AAPS Annual Meeting, San Francisco, Pharm. Sci. Suppl. Vol 1 PDD 3606: S-534. Abstract

  28. Büyüktimkin, N., Büyüktimkin, S., and Rytting, J.H. (1997) Chemical means of transdermal drug permeation enhancement. Ghosh, T. K., Pfister, W. R. and Yum, S. I. (Eds) in Transdermal and Topical drug delivery Systems. Interpharm Press. Paper

  29. Büyüktimkin, S., Büyüktimkin, N., Yeager, J.L., and Rytting, J. H. (1996) Investigation of enhancing effects of N,N-dialkylamino alkanol alkanoates. AAPS Eleventh Annual Meeting, Abstract 7552. Pharm. Res. 13: S-70. Abstract

  30. Büyüktimkin, S., Büyüktimkin, N., Beh, R., and Rytting, J. H. (1996) Influence of penetration enhancers on the in vitro permeation, skin retention, and partition coefficient of ketoprofen through shed snake skin. AAPS Eleventh Annual Meeting, Abstract 7553. Pharm. Res. 13: S-371. Abstract

  31. Büyüktimkin, N., Büyüktimkin, S., Beh, R., Yeager, J. L., and Rytting, J. H. (1996) Effects of ethanol and the penetration enhancer dodecyl-2-(N,N-dimethylamino)-propionate (DDAIP) on the permeation of ketoprofen through shed snake skin. AAPS Eleventh Annual Meeting, Abstract 7554. Pharm. Res. 13: S-371. Abstract

  32. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1996) Interaction of indomethacin with a new penetration enhancer, dodecyl-2-(N,N-dimethylamino)-propionate (DDAIP): It's effect on transdermal delivery. Int. J. Pharm. 127: 245-253. Paper

  33. Rytting, J. H., Büyüktimkin, S., and Büyüktimkin, N. (1996) Synthesis and evaluation of several alkyl N,N-dimethylamino alkanoates as transdermal penetration enhancers. 11th American Chemical Society National Meeting, New Orleans, LA, March 24-28. Abstract

  34. Büyüktimkin, T., Büyüktimkin, S., and Rytting, J.H. (1996) Permeation of a penetration enhancer DDAIP (dodecyl-2-(N,N-dimethylamino)-propionate) through shed snake skin and its metabolism in the skin. Summer Undergraduate Research Symposium, School of Pharmacy, The University of Kansas, Abstract # 3, July 24, Lawrence, Kansas. Abstract

  35. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J.H. (1995) Physicochemical characteristics of some penetration enhancers and their effects on epithelial membrane lipids domains and the transdermal delivery of some drugs. AAPS Tenth Annual Meeting, Abstract 7372. Pharm. Res. 12: S-285. Abstract

  36. Büyüktimkin, N., Büyüktimkin, S., and Rytting, J. H. (1995) Influence of penetration enhancers on the in vitro permeation of ion-paired clonidine and diphenhydramine through shed snake skin. AAPS Tenth Annual Meeting, Abstract 7373. Pharm. Res. 12: S-286. Abstract

  37. Urtti, A. (1995) Mechanism of transdermal penetration enhancement. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 22: 115-116. Abstract

  38. Büyüktimkin, N., Büyüktimkin, S., and Rytting, J. H. (1995) Chapter 4.2.: Alky-N,N-disubstituted amino acetates. E. Smith and H. I. Maibach (Eds) in Percutaneous penetration enhancers, CRC Press, Boca Raton. Book Chapter

  39. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J.H. (1995) Preparation and enhancing effect of 1-(N,N-dimethylamino)-2-propanol dodecanoate (DAIPD) on transepidermal penetration of clonidine, hydrocortisone, and indomethacin through shed snake skin. Int. J. Pharm. 118: 113-119. Paper

  40. Hirvonen, J., Rajala, R., Vihervaara, P., Laine, E., Paronen, P., and Urtti, A. (1994) Mechanism and reversibility of penetration enhancer action in the skin - A DSC study. Eur. J. Pharm. Biopharm, 40: 81-85. Paper

  41. Hirvonen, J. (1994) Enhancement of transdermal drug penetration with dodecyl N,N-dimethylamino acetate and iontophoresis. Ph.D. Thesis, Pharmaceutical Sciences, Kuopio, Finland: Kuopio University Publication, A 1 Paper

  42. Ruland, A., Kreuter, J., and Rytting, J. H. (1994) Transdermal delivery of the tetrapeptide hisetal [melanotropin (6-9)] I. Effect of various penetration enhancers: in vitro study across hairless mouse skin. Int. J. Pharm. 101: 57-61. Paper

  43. Ruland, A., J. Kreuter, J., and J.H. Rytting, J. H. (1994) Transdermal delivery of the tetrapeptide hisetal [melanotropin (6-9)] II. Effect of various penetration enhancers: in vitro study across hairless mouse skin. Int. J. Pharm. 103: 77-80. Paper

  44. Turunen, T. M., Urtti, A., Paronen, P., Audus, K. L., and Rytting, J. H. (1994) Effect of some penetration enhancers on epithelial membrane lipid domains: Evidence from fluorescence spectroscopy studies. Pharm. Res. 11: 288-294. Paper

  45. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1993) Synthesis and enhancing effect of dodecyl-N,N-dimethylamino-2-propionate (DDAIP) on the transepidermal delivery of indomethacin, clonidine, and hydrocortisone. Pharm. Res. 10: 1632-1637. Paper

  46. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1993) Preparation and absorption promoting effect of 1-(N,N-dimethylamino)-2-propanol dodecanoate (DAIPD) as a new biodegradable penetration enhancer, on transepidermal penetration of clonidine, hydrocortisone, and indomethacin through shed snake skin. AAPS Eighth Annual Meeting, Abstract 7265. Pharm. Res. 10: S-241. Abstract

  47. Büyüktimkin, S., Büyüktimkin, N., and J. H. Rytting, J. H. (1993) Studies on the interaction between indomethacin and a new penetration enhancer dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP) and an evaluation of it's effect on transdermal delivery. AAPS Eighth Annual Meeting, Abstract 7266. Pharm. Res. 10: S-241. Paper

  48. Hirvonen, J., Sutinen, R., Paronen, P., and Urtti, A. (1993) Transdermal penetration enhancers in rabbit pinna skin: Duration of action, skin irritation, and in vivo/ in vitro comparison. Int. J. Pharm. 99: 253-261. Paper

  49. Hirvonen, J., Kontturi, K., Murtomaki, L., Paronen, P., and Urtti, A. (1993) Transdermal iontophoresis of sotalol and salicylate; the effect of skin charge and penetration enhancers. J. Contr. Rel. 26: 109-117. Paper

  50. Hirvonen, J., Paronen, P., and Urtti, A. (1993) Concentration-effect relationships of transdermal penetration enhancers. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 20: 408-409. Abstract

  51. Kontturi, K., Murtomaki, L., Hirvonen, J., Paronen, P., and Urtti, A. (1993) Electrochemical characterization of human skin, by impedance spectroscopy. The effect of penetration enhancers. Pharm. Res. 10: 381-385. Paper

  52. Turunen, T. M., Büyüktimkin, S., Büyüktimkin, N., Urtti, A., Paronen, P., and Rytting, J. H. (1993) Enhanced delivery of 5-Fluorouracil through shed snake skin by two new transdermal penetration enhancers. Int. J. Pharm. 92: 89-95. Paper

  53. Turunen, T. M., Urtti, A., and Paronen, P. (1993) Effect of 20 some penetration enhancers on epithelial membrane lipids. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 20: 444-445. Paper

  54. Büyüktimkin, N., Büyüktimkin, S., and Rytting, J. H. (1992) The effect of delipidization on the penetration enhancement of indomethacin, clonidine and hydrocortisone through shed snake skin in the presence of Azone and DDAIP (Dodecyl N,N-dimethylamino isopropionate). AAPS Seventh Annual Meeting, Abstract 7261. Pharm. Res. 9: S-234. Abstract

  55. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1992) Penetration enhancement of indomethacin, clonidine and hydrocortisone by some new alkyl a-(N,N-dimethylamino) alkanoates. AAPS Seventh Annual Meeting, Abstract 7262. Pharm. Res. 9: S-234. Paper

  56. Wong, O., Nishihata, T., and Rytting, J. H. (January 21, 1992) Biodegradable absorption enhancers. U.S. Patent 5,082,866. Patent

  57. Hirvonen, J., Murtomaki, L., Kontturi, K., Paronen, P., and Urtti, A. (1992) Transdermal permeation of model anions and cations; Effect of skin charge, iontophoresis and penetration enhancers. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 19: 452-453. Abstract

  58. Hirvonen, J., Vihervaara, P., Laine, E., Paronen, P., and Urtti, A. (1992) Reversibility of penetration enhancer action in rabbit pinna skin in vivo - A DSC study. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 19: 454-455. Paper

  59. Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1991) New alkyl a-(N,N-dimethylamino)-alkanoates as transdermal penetration enhancers. AAPS Sixth Annual Meeting, Abstract 7049. Pharm. Res. 8: S-139. Abstract

  60. Büyüktimkin, N., Büyüktimkin, S., and Rytting, J. H. (1991) Stability of several alkyl N,N-dimethylamino acetates having potential as biodegradable transdermal penetration enhancers. AAPS Sixth Annual Meeting, Abstract Pharm. Res. 8: S-139. Abstract

  61. Gant, J. G., Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1991) Evaluation of two unsaturated cyclic ureas as biodegradable transdermal penetration enhancers with basic and neutral drugs. Summer Undergraduate Research Symposium, School of Pharmacy, The University of Kansas, Abstract 13, July 30, Lawrence, Kansas.

  62. Hirvonen, J., Paronen, P., and Urtti, A. (1991) Reversible enhancement of transdermal propranolol by dodecyl N,N-dimethylamino acetate. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 18: 31 (podium). Paper

  63. Hirvonen, J., Rytting, J. H., Paronen, P., and Urtti, A. (1991) Dodecyl N,N-dimethylamino acetate and azone enhance drug penetration across human, snake, and rabbit skin. Pharm. Res. 8: 933-937.

  64. Wongpayapkul, L., and Chow, D. (1991) Comparative evaluation of various enhancers on the transdermal permeation of propranolol hydrochloride. AAPS Sixth Annual Meeting, Abstract 7053. Pharm. Res. 8: S-140. Abstract

  65. Turunen, T. M., Büyüktimkin, S., Büyüktimkin, N., and Rytting, J. H. (1991) Enhanced delivery of 5-Fluorouracil through shed snake skin by two new transdermal penetration enhancers. AAPS Sixth Annual Meeting, Abstract Pharm. Res. 8: S-138. Abstract

  66. Wong, O., Nishihata, T., and Rytting, J. H. (December 25, 1990) Biodegradable absorption enhancers. U.S. Patent 4,980,378. Patent

  67. Hirvonen, J., Rytting, J. H., Paronen, P., and Urtti, A. (1990) Shed snakeskin and rabbit pinna skin as model membranes for human skin during permeation studies. AAPS Fifth Annual Meeting, Abstract 7316. Pharm. Res. 7: S-190. Abstract

  68. Hirvonen, J., Rytting, J. H., Paronen, P., and Urtti, A. (1990) Dodecyl N,N-dimethylamino acetate as a transdermal penetration enhancer in human skin. AAPS Fifth Annual Meeting, Abstract 7341. Pharm. Res. 7: S-197. Abstract

  69. Fleeker, C., Wong, O., and Rytting, J. H. (1989) Facilitated transport of basic and acidic drugs in solutions through snakeskin by a new enhancer dodecyl-N,N-dimethylamino acetate. Pharm. Res. 6: 443-448. Paper

  70. Wong, O., Huntington, J., Nishihata, T., and Rytting. J. H. (1989) New alkyl N,N-dialkyl-substituted amino acetates as transdermal penetration enhancers. Pharm. Res. 6: 286-295. Abstract

  71. Wong, O., Tsuzuki, N., Nghiem, B., Kuenhoff, J., Itoh, T., Masaki, K., Huntington, J., Konishi, R., Rytting, J. H., and Higuchi, T. (1989) Unsaturated cyclic ureas as new non-toxic biodegradable penetration enhancers. II. Evaluation study. Int. J. Pharm. 52: 191-202. Abstract

  72. Higuchi, T., and Wong, O. (1989) Imidazolin-2-ones. U.S. Patent 4,845,233. Patent

  73. Wong, O., Huntington, J., Nishihata, T., and Rytting, J. H. (1988) Alkyl N,N-dialkyl substituted amino acetates as transdermal penetration enhancers. AAPS Third Annual Meeting, Abstract 995. Pharm. Res. 5: S-121. Abstract

  74. Wong, O., Huntington, J., Konishi, R., Rytting, J. H., and Higuchi, T. (1988) Unsaturated cyclic ureas as new non-toxic biodegradable penetration enhancers. I. Synthesis. J. Pharm. Sci. 77: 967-971. Paper
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